Blood picture and phagocytosis in immunised BALB/c mice with the lipopolysaccharide extracted from Klebsiella pneumoniae against infection with secondary hydatid disease

• Main Authors: Asmaa Abdulaziz Ali (Author), Ibrahim Ali (Author)
• Format: Book
• Published: College of Education for Pure Sciences, 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1812-125X; 2664-2530; 10.33899/edusj.2010.58243
• Keywords: blood picture; phagocytosis; lipopolysaccharide; klebsiella pneumoniae; hydatid disease; Education; L; Science (General); Q1-390
• Source: مجلة التربية والعلم, Vol 23, Iss 2, Pp 23-41 (2010)

ABSTRACT<br /> The study tested the effect of the lipopolysaccharide, which was extracted from Klebsiella pneumoniae, on immune response of BALB/c mice infected with secondary hydatid disease caused by experimental infection with Echinococcus granulosus protoscolices.<br /> The immunopathological changes accompanied with secondary hydatid disease in mice treated with LPS were followed in comparison with the positive and negative control group along 3-5 months period of the experiments. Criteria taken into consideration included the changes in the total and differential count of WBCs, and non-specific (innate) immune response, expressed by the change in the phagocytic index.<br /> Results of the present study revealed an increase in the means of total and differential count of WBCs, expressed by increase in the number of lymphocytes accompanied by a decrease in number of monocytes, neutrophils and eosinophils in treated mice. An increase in the nonspecific immune responses is represented by increase in the mean of phagocytic index.<br /> Therefore, it may be concluded that the lipopolysaccharide extracted from Klebsiella pneumoniae can be used as a non-toxic stimulator of non-specific immunity against infection with secondary hydatid disease.