Effects of curcumin and demethoxycurcumin on amyloid-β precursor and tau proteins through the internal ribosome entry sites: A potential therapeutic for Alzheimer's disease

• Main Authors: Oliver B. Villaflores (Author), Ying-Ju Chen (Author), Chih-Ping Chen (Author), Jui-Ming Yeh (Author), Tzong-Yuan Wu (Author)
• Format: Book
• Published: Elsevier, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: This study aims to determine the effects of curcumin and demethoxycurcumin on the internal ribosome entry site of the amyloid-β precursor protein (APP) and tau protein through a bi-cistronic reporter assay for screening of anti-Alzheimer's disease agents. Materials and Methods: A bi-...