Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B

• Main Authors: Lu Yonghai (Author), Zheng Yue (Author), Liu Xinru (Author), Liang Xu (Author), Ngai Saiming (Author), Li Tiejun (Author), Zhang Weidong (Author)
• Format: Book
• Published: BMC, 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p><it>Radix Salvia miltiorrhiza </it>(<it>Danshen</it>) has been used as a principal herb in treating cardiovascular diseases in Chinese medicine. Salvianolic acid B (SA-B), a water-soluble active component of <it>Danshen</it>, was found to have anti-myocardial ischemia (anti-MI) effect. This study aims to investigate mechanisms of SA-B on MI.</p> <p>Methods</p> <p>Five conventional Western medicines (isosorbide dinitrate, verapamil, propranolol, captopril and trimethazine) with different mechanisms for treating cardiovascular diseases were selected as positive references to compare with SA-B in changing of the metabolomic profiles in MI rats under treatment. Potential mechanisms of SA-B were further investigated in H9C2 cell line.</p> <p>Results</p> <p>The metabolomic profiles between SA-B- and propranolol-treated MI rats were similar, since there was a big overlap between the two groups in the PLS-DA score plot. Finally, it was demonstrated that SA-B exhibited a protective effect on MI mainly by decreasing the concentration of cyclic adenosine monophosphate (cAMP) and Ca²⁺and inhibiting protein kinase A (PKA).</p> <p>Conclusion</p> <p>SA-B and propanolol exhibited similar metabolomic profiles, indicating that the two drugs might have a similar mechanism.</p>

Item Description

10.1186/1749-8546-7-6
1749-8546