A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation

• Main Authors: Jehangir N. Ahmed (Author), Radiya G. Ali (Author), Nicholas Warr (Author), Heather M. Wilson (Author), Helen M. Bellchambers (Author), Kristen S. Barratt (Author), Amelia J. Thompson (Author), Ruth M. Arkell (Author)
• Format: Book
• Published: The Company of Biologists, 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The ZIC transcription factors are key mediators of embryonic development and ZIC3 is the gene most commonly associated with situs defects (heterotaxy) in humans. Half of patient ZIC3 mutations introduce a premature termination codon (PTC). In vivo, PTC-containing transcripts might be targete...