Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture

• Main Authors: Kitto Kelley F (Author), Podetz-Pedersen Kelly M (Author), Riedl Maureen S (Author), Belur Lalitha R (Author), Schuster Daniel J (Author), Vulchanova Lucy (Author), Wilcox George L (Author), McIvor R Scott (Author), Fairbanks Carolyn A (Author)
• Format: Book
• Published: SAGE Publishing, 2010-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Neuronal transduction by adeno-associated viral (AAV) vectors has been demonstrated in cortex, brainstem, cerebellum, and sensory ganglia. Intrathecal delivery of AAV serotypes that transduce neurons in dorsal root ganglia (DRG) and...