Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast <i>Candida albicans</i>

• Egile Nagusiak: Olena P. Ishchuk (Egilea), Olov Sterner (Egilea), Ulf Ellervik (Egilea), Sophie Manner (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2019-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.
• Notes: 2079-6382; 10.3390/antibiotics9010010
• Keywords: fucoside; xyloside; <i>candida albicans</i>; biofilm; Therapeutics. Pharmacology; RM1-950
• Source: Antibiotics, Vol 9, Iss 1, p 10 (2019)

The opportunistic human fungal pathogen <i>Candida albicans</i> relies on cell morphological transitions to develop biofilm and invade the host. In the current study, we developed new regulatory molecules, which inhibit the morphological transition of <i>C. albicans</i> from yeast-form cells to cells forming hyphae. These compounds, benzyl &#945;-<span style="font-variant: small-caps;">l</span>-fucopyranoside and benzyl &#946;-<span style="font-variant: small-caps;">d</span>-xylopyranoside, inhibit the hyphae formation and adhesion of <i>C. albicans</i> to a polystyrene surface, resulting in a reduced biofilm formation. The addition of cAMP to cells treated with &#945;-<span style="font-variant: small-caps;">l</span>-fucopyranoside restored the yeast-hyphae switch and the biofilm level to that of the untreated control. In the &#946;-<span style="font-variant: small-caps;">d</span>-xylopyranoside treated cells, the biofilm level was only partially restored by the addition of cAMP, and these cells remained mainly as yeast-form cells.