m6A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis

• Main Authors: Li Chen (Author), Siwei Xia (Author), Feixia Wang (Author), Yuanyuan Zhou (Author), Shuqi Wang (Author), Ting Yang (Author), Yang Li (Author), Min Xu (Author), Ya Zhou (Author), Desong Kong (Author), Zili Zhang (Author), Jiangjuan Shao (Author), Xuefen Xu (Author), Feng Zhang (Author), Shizhong Zheng (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The roles of nuclear receptor subfamily 1 group d member 1 (NR1D1) and the circadian clock in liver fibrosis remain unclear. Here, we showed that liver clock genes, especially NR1D1, were dysregulated in mice with carbon tetrachloride (CCl4)-induced liver fibrosis. In turn, disruption of the circadi...