Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice

• Main Authors: Elham Hakimizadeh (Author), Faezeh Jandaghi (Author), Mojdeh Hajmohammadi (Author), Iman Fatemi (Author), Ayat Kaeidi (Author), Ali Sham‌sizadeh (Author), Mohammad Allahtavakoli* (Author)
• Format: Book
• Published: Iranian Society of Pharmacognosy, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<strong>Background and objectives:</strong> Menopause is associated with depression as well as emotional and memory disorders. Based on the anti-inflammatory and antioxidant effects of pistachio, its effect on depression, cognitive function, anxiety and physical power in ovariectomized mice was investigated.<strong> Methods: </strong>In the current study, fifty female mice were used. They were aliquoted into five groups: control, ovariectomy (OVX), ovariectomy + DMSO, ovariectomy +10 mg/kg pistachioextract and Ovariectomy +100 mg/kg pistachio extract. In order to prepare the required extract, pistachio nuts were powdered (100 g) and macerated in 1 L of ethanol (80%) for 72 h. Pistachio extract was used orally once a day in ovariectomized mice for sixty days. Anxiety, depression, working memory and physical power were evaluated by the Elevated plus-maze (EPM) test, Forced swimming test (FST), Y maze and swimming exhaustion test, respectively. <strong>Results: </strong>The results showed that extract of pistachio (more potentially at the dose of 100 mg/kg) decreased anxiety-like behaviors and depression; besides, increase in working memory and physical power was observed in the ovariectomized mice. <strong>Conclusion:</strong> The findings of the current investigation suggest that pistachio extract could be used as a potential strategy for the attenuation of ovariectomy-related manifestation

Item Description

2345-4458
2345-5977
10.22127/rjp.2019.93515