Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice
<strong>Background and objectives:</strong> Menopause is associated with depression as well as emotional and memory disorders. Based on the anti-inflammatory and antioxidant effects of pistachio, its effect on depression, cognitive function, anxiety and physical power in ovariectomized m...
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Iranian Society of Pharmacognosy,
2019-10-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_6d9f75527cf24d16b88897ca3d2974ab | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Elham Hakimizadeh |e author |
| 700 | 1 | 0 | |a Faezeh Jandaghi |e author |
| 700 | 1 | 0 | |a Mojdeh Hajmohammadi |e author |
| 700 | 1 | 0 | |a Iman Fatemi |e author |
| 700 | 1 | 0 | |a Ayat Kaeidi |e author |
| 700 | 1 | 0 | |a Ali Shamsizadeh |e author |
| 700 | 1 | 0 | |a Mohammad Allahtavakoli* |e author |
| 245 | 0 | 0 | |a Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice |
| 260 | |b Iranian Society of Pharmacognosy, |c 2019-10-01T00:00:00Z. | ||
| 500 | |a 2345-4458 | ||
| 500 | |a 2345-5977 | ||
| 500 | |a 10.22127/rjp.2019.93515 | ||
| 520 | |a <strong>Background and objectives:</strong> Menopause is associated with depression as well as emotional and memory disorders. Based on the anti-inflammatory and antioxidant effects of pistachio, its effect on depression, cognitive function, anxiety and physical power in ovariectomized mice was investigated.<strong> Methods: </strong>In the current study, fifty female mice were used. They were aliquoted into five groups: control, ovariectomy (OVX), ovariectomy + DMSO, ovariectomy +10 mg/kg pistachioextract and Ovariectomy +100 mg/kg pistachio extract. In order to prepare the required extract, pistachio nuts were powdered (100 g) and macerated in 1 L of ethanol (80%) for 72 h. Pistachio extract was used orally once a day in ovariectomized mice for sixty days. Anxiety, depression, working memory and physical power were evaluated by the Elevated plus-maze (EPM) test, Forced swimming test (FST), Y maze and swimming exhaustion test, respectively. <strong>Results: </strong>The results showed that extract of pistachio (more potentially at the dose of 100 mg/kg) decreased anxiety-like behaviors and depression; besides, increase in working memory and physical power was observed in the ovariectomized mice. <strong>Conclusion:</strong> The findings of the current investigation suggest that pistachio extract could be used as a potential strategy for the attenuation of ovariectomy-related manifestation | ||
| 546 | |a EN | ||
| 690 | |a Mice | ||
| 690 | |a ovariectomy | ||
| 690 | |a Pistacia vera | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Research Journal of Pharmacognosy, Vol 6, Iss 4, Pp 45-51 (2019) | |
| 787 | 0 | |n http://www.rjpharmacognosy.ir/article_93515_5a29bf5c90ed91f497fa61f3cba816b2.pdf | |
| 787 | 0 | |n https://doaj.org/toc/2345-4458 | |
| 787 | 0 | |n https://doaj.org/toc/2345-5977 | |
| 856 | 4 | 1 | |u https://doaj.org/article/6d9f75527cf24d16b88897ca3d2974ab |z Connect to this object online. |