Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress

• Main Authors: Sunwha Park (Author), Eunjin Kwon (Author), Gain Lee (Author), Young-Ah You (Author), Soo Min Kim (Author), Young Min Hur (Author), Sooyoung Jung (Author), Yongho Jee (Author), Mi Hye Park (Author), Sung Hun Na (Author), Young-Han Kim (Author), Geum Joon Cho (Author), Jin-Gon Bae (Author), Soo-Jeong Lee (Author), Sun Hwa Lee (Author), Young Ju Kim (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antiox12111916; 2076-3921
• Keywords: 8-hydroxy-2-deoxyguanosine; biomarker; indoor air; low birth weight; particulate matter; preterm birth; Therapeutics. Pharmacology; RM1-950
• Source: Antioxidants, Vol 12, Iss 11, p 1916 (2023)

Particulate matter 2.5 (PM_2.5) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM_2.5 affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM_2.5 exposure levels. As a multicenter prospective cohort study, we measured the indoor PM_2.5 concentration and inflammatory and oxidative stress markers. The PM_2.5 concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m³, which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m³) (<i>p</i> = 0.02). When the newborns were divided by sex, the PM_2.5 concentration of the LBW group was 27.89 μg/m³ in male infants, which was significantly higher than that of the NBW group (26.26 μg/m³) (<i>p</i> = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (<i>p</i> < 0.01, <i>p</i> = 0.01). This study showed an association between PM_2.5, oxidative stress, and fetal growth, with the PTB group being more vulnerable.