Recent Advances on the Regulations of Organic Anion Transporters
The organic anion transporter (OAT) family of over 10 members within the solute carrier (SLC) superfamily of membrane proteins plays critical roles in facilitating the flux of negatively charged molecules in and out of cell membranes. These anionic molecules include various endogenous and exogenous...
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MDPI AG,
2024-10-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_6dc96dcba3764a73a7b4deb8af4a2d8d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Zhou Yu |e author |
| 700 | 1 | 0 | |a Guofeng You |e author |
| 245 | 0 | 0 | |a Recent Advances on the Regulations of Organic Anion Transporters |
| 260 | |b MDPI AG, |c 2024-10-01T00:00:00Z. | ||
| 500 | |a 10.3390/pharmaceutics16111355 | ||
| 500 | |a 1999-4923 | ||
| 520 | |a The organic anion transporter (OAT) family of over 10 members within the solute carrier (SLC) superfamily of membrane proteins plays critical roles in facilitating the flux of negatively charged molecules in and out of cell membranes. These anionic molecules include various endogenous and exogenous compounds such as signaling molecules, nutrients, metabolites, toxins, and drugs. Therefore, OATs actively contribute to the systemic homeostasis and efficacy of therapeutics. This article provides a brief overview on recent advances in the understanding of the regulatory mechanisms that control the expression and activity of OATs in both health and diseases. | ||
| 546 | |a EN | ||
| 690 | |a drug transporter | ||
| 690 | |a organic anion transporter | ||
| 690 | |a regulation | ||
| 690 | |a post-translational modification | ||
| 690 | |a diseases | ||
| 690 | |a drug disposition | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 16, Iss 11, p 1355 (2024) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/16/11/1355 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/6dc96dcba3764a73a7b4deb8af4a2d8d |z Connect to this object online. |