Silymarin-laden PVP-PEG polymeric composite for enhanced aqueous solubility and dissolution rate: Preparation and in vitro characterization
The aim of this work was to develop, optimize and characterize a silymarin-laden polyvinylpyrrolidone (PVP)-polyethylene glycol (PEG) polymeric composite to resolve low aqueous solubility and dissolution rate problem of the drug. A number of silymarin-laden polymeric formulations were fabricated wit...
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Elsevier,
2019-02-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_6e2b2a8ffa9c49f3b7578b4b7eb0216f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Abid Mehmood Yousaf |e author |
| 700 | 1 | 0 | |a Usman Rashid Malik |e author |
| 700 | 1 | 0 | |a Yasser Shahzad |e author |
| 700 | 1 | 0 | |a Tariq Mahmood |e author |
| 700 | 1 | 0 | |a Talib Hussain |e author |
| 245 | 0 | 0 | |a Silymarin-laden PVP-PEG polymeric composite for enhanced aqueous solubility and dissolution rate: Preparation and in vitro characterization |
| 260 | |b Elsevier, |c 2019-02-01T00:00:00Z. | ||
| 500 | |a 2095-1779 | ||
| 500 | |a 10.1016/j.jpha.2018.09.003 | ||
| 520 | |a The aim of this work was to develop, optimize and characterize a silymarin-laden polyvinylpyrrolidone (PVP)-polyethylene glycol (PEG) polymeric composite to resolve low aqueous solubility and dissolution rate problem of the drug. A number of silymarin-laden polymeric formulations were fabricated with different quantities of PVP K-30 and PEG 6000 by the solvent-evaporation method. The effect of PVP K-30 and PEG 6000 on the aqueous solubility and dissolution rate was investigated. The optimized formulation and its constituents were characterized using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) techniques. Both the PEG 6000 and PVP K-30 positively affected the aqueous solubility and dissolution rate of the drug. In particular, a formulation consisting of silymarin, PVP K-30 and PEG 6000 (0.25/1.5/1.5, w/w/w) furnished the highest solubility (24.39±2.95 mg/mL) and an excellent dissolution profile (~100% in 40 min). The solubility enhancement with this formulation was ~1150-fold as compared to plain silymarin powder. Moreover, all the constituents existed in the amorphous state in this silymarin-laden PVP-PEG polymeric composite. Accordingly, this formulation might be a promising tool to administer silymarin with an enhanced effect via the oral route. Keywords: Silymarin, Hydrophilic polymers, Inclusion, Solid dispersion, Aqueous solubility, Dissolution rate | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmaceutical Analysis, Vol 9, Iss 1, Pp 34-39 (2019) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2095177918303149 | |
| 787 | 0 | |n https://doaj.org/toc/2095-1779 | |
| 856 | 4 | 1 | |u https://doaj.org/article/6e2b2a8ffa9c49f3b7578b4b7eb0216f |z Connect to this object online. |