Biotransformation of ginsenosides Rb<sub>1</sub>, Rg<sub>3 </sub>and Rh<sub>2 </sub>in rat gastrointestinal tracts
<p>Abstract</p> <p>Background</p> <p>Ginsenosides such as Rb<sub>1</sub>, Rg<sub>3 </sub>and Rh<sub>2 </sub>are major bioactive components of <it>Panax ginseng</it>. This <it>in vivo </it>study investigates the...
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| Main Authors: | , |
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| Format: | Book |
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BMC,
2010-05-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | <p>Abstract</p> <p>Background</p> <p>Ginsenosides such as Rb<sub>1</sub>, Rg<sub>3 </sub>and Rh<sub>2 </sub>are major bioactive components of <it>Panax ginseng</it>. This <it>in vivo </it>study investigates the metabolic pathways of ginsenosides Rb<sub>1</sub>, Rg<sub>3 </sub>and Rh<sub>2 </sub>orally administered to rats.</p> <p>Methods</p> <p>High performance liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (MS-MS) techniques, particularly liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS), were used to identify the metabolites.</p> <p>Results</p> <p>Six metabolites of Rb<sub>1</sub>, six metabolites of Rg<sub>3 </sub>and three metabolites of Rh<sub>2 </sub>were detected in the feces samples of the rats. Rh<sub>2 </sub>was a metabolite of Rb<sub>1 </sub>and Rg<sub>3</sub>, whereas Rg<sub>3 </sub>was a metabolite of Rb<sub>1</sub>. Some metabolites such as protopanaxadiol and monooxygenated protopanaxadiol are metabolites of all three ginsenosides.</p> <p>Conclusion</p> <p>Oxygenation and deglycosylation are two major metabolic pathways of the ginsenosides in rat gastrointestinal tracts.</p> |
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| Item Description: | 10.1186/1749-8546-5-19 1749-8546 |