TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

• Autors principals: Robin Sachdeva (Autor), Andrea Schlotterer (Autor), Dagmar Schumacher (Autor), Christin Matka (Autor), Ilka Mathar (Autor), Nadine Dietrich (Autor), Rebekka Medert (Autor), Ulrich Kriebs (Autor), Jihong Lin (Autor), Peter Nawroth (Autor), Lutz Birnbaumer (Autor), Thomas Fleming (Autor), Hans-Peter Hammes (Autor), Marc Freichel (Autor)
• Format: Llibre
• Publicat: Elsevier, 2018-03-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Objective: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this study, we use Trpc1/4/5/6−/− compound knockout mice to analyze the contribution of...