Rapid detection of myeloid neoplasm fusions using single-molecule long-read sequencing.

• Main Authors: Olga Sala-Torra (Author), Shishir Reddy (Author), Ling-Hong Hung (Author), Lan Beppu (Author), David Wu (Author), Jerald Radich (Author), Ka Yee Yeung (Author), Cecilia C S Yeung (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recurrent gene fusions are common drivers of disease pathophysiology in leukemias. Identifying these structural variants helps stratify disease by risk and assists with therapy choice. Precise molecular diagnosis in low-and-middle-income countries (LMIC) is challenging given the complexity of assays...