Chitosan-Based Nanoparticles for Intracellular Delivery of ISAV Fusion Protein cDNA into Melanoma Cells: A Path to Develop Oncolytic Anticancer Therapies

• Main Authors: Claudia Robles-Planells (Author), Giselle Sánchez-Guerrero (Author), Carlos Barrera-Avalos (Author), Silvia Matiacevich (Author), Leonel E. Rojo (Author), Jorge Pavez (Author), Edison Salas-Huenuleo (Author), Marcelo J. Kogan (Author), Alejandro Escobar (Author), Luis A. Milla (Author), Ricardo Fernandez (Author), Mónica Imarai (Author), Eugenio Spencer (Author), Juan Pablo Huidobro-Toro (Author), Claudio Acuña-Castillo (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation and immunogenic cell death of eukaryotic cells. We have previously demonstrat...