Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C-glycoside cleaving enzyme and an O- to C-glycoside isomerase

• Main Authors: Pengfei He (Author), Sha Wang (Author), Sen Li (Author), Siqi Liu (Author), Shuqi Zhou (Author), Jing Wang (Author), Jiayue Tao (Author), Dongdong Wang (Author), Rufeng Wang (Author), Wenfu Ma (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The C-glycosidic bond that connects the sugar moiety with aglycone is difficult to be broken or made due to its inert nature. The knowledge of C-glycoside breakdown and synthesis is very limited. Recently, the enzyme DgpA/B/C cascade from a human intestinal bacterium PUE was identified to specifical...