PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants
Morphine has large pharmacokinetic variability, which is further complicated by developmental changes in neonates and small infants. The impacts of organic cation transporter 1 (OCT1) genotype and changes in blood‐flow on morphine clearance (CL) were previously demonstrated in children, whereas chan...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2018-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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