Role of determination of molecular genetic markers in the diagnosis and prediction of the course of cervix uteri diseases
Forty-six patients with various cervix uteri (CU) diseases were examined and treated. The examinees' age was 21 to 72 years (mean age 37.4 ± 1.1 years).In 16 patients, the rate of N33, MLH1, p16 gene hypermethylation was determined in the tissue samples of the CU in its various dis- eases: ther...
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| Main Authors: | , , |
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| Format: | Book |
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ABV-press,
2014-08-01T00:00:00Z.
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| Summary: | Forty-six patients with various cervix uteri (CU) diseases were examined and treated. The examinees' age was 21 to 72 years (mean age 37.4 ± 1.1 years).In 16 patients, the rate of N33, MLH1, p16 gene hypermethylation was determined in the tissue samples of the CU in its various dis- eases: there was hypermethylation of the p16 (83%) and MLH1 (66%), and N33 (33%) genes in CU leukoplakia; the p16 (100%) and MLH1 (100%), and N33 (62%) genes in CU dysplasia, and the p16 (100%) and MLH1 (50%), and N33 (50%) genes in squamous cell carcinoma of the CU.A follow-up of patients with established gene hypermethylation revealed a recurrence in 50% of cases of CU leukoplasia and in 37.5% of cases of CU dysplasias. No recurrences were observed in a group of 30 patients without abnormal gene methylation in CU tissues during the follow-up. |
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| Item Description: | 1994-4098 1999-8627 10.17650/1994-4098-2010-0-2-93-98 |