Chlamydia trachomatis Immune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms
Genital C. trachomatis infections typically last for many months in women. This has been attributed to several strategies by which C. trachomatis evades immune detection, including well-described methods by which C. trachomatis decreases the cell surface expression of the antigen presenting molecule...
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| Format: | Book |
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Hindawi Limited,
2011-01-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_6f08c257468c4d4a92986d1ac80c0cc1 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Joyce A. Ibana |e author |
| 700 | 1 | 0 | |a Danny J. Schust |e author |
| 700 | 1 | 0 | |a Jun Sugimoto |e author |
| 700 | 1 | 0 | |a Takeshi Nagamatsu |e author |
| 700 | 1 | 0 | |a Sheila J. Greene |e author |
| 700 | 1 | 0 | |a Alison J. Quayle |e author |
| 245 | 0 | 0 | |a Chlamydia trachomatis Immune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms |
| 260 | |b Hindawi Limited, |c 2011-01-01T00:00:00Z. | ||
| 500 | |a 1064-7449 | ||
| 500 | |a 1098-0997 | ||
| 500 | |a 10.1155/2011/420905 | ||
| 520 | |a Genital C. trachomatis infections typically last for many months in women. This has been attributed to several strategies by which C. trachomatis evades immune detection, including well-described methods by which C. trachomatis decreases the cell surface expression of the antigen presenting molecules major histocompatibility complex (MHC) class I, MHC class II, and CD1d in infected genital epithelial cells. We have harnessed new methods that allow for separate evaluation of infected and uninfected cells within a mixed population of chlamydia-infected endocervical epithelial cells to demonstrate that MHC class I downregulation in the presence of C. trachomatis is mediated by direct and indirect (soluble) factors. Such indirect mechanisms may aid in priming surrounding cells for more rapid immune evasion upon pathogen entry and help promote unfettered spread of C. trachomatis genital infections. | ||
| 546 | |a EN | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 690 | |a Infectious and parasitic diseases | ||
| 690 | |a RC109-216 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Infectious Diseases in Obstetrics and Gynecology, Vol 2011 (2011) | |
| 787 | 0 | |n http://dx.doi.org/10.1155/2011/420905 | |
| 787 | 0 | |n https://doaj.org/toc/1064-7449 | |
| 787 | 0 | |n https://doaj.org/toc/1098-0997 | |
| 856 | 4 | 1 | |u https://doaj.org/article/6f08c257468c4d4a92986d1ac80c0cc1 |z Connect to this object online. |