Chlamydia trachomatis Immune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms

Genital C. trachomatis infections typically last for many months in women. This has been attributed to several strategies by which C. trachomatis evades immune detection, including well-described methods by which C. trachomatis decreases the cell surface expression of the antigen presenting molecule...

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Main Authors: Joyce A. Ibana (Author), Danny J. Schust (Author), Jun Sugimoto (Author), Takeshi Nagamatsu (Author), Sheila J. Greene (Author), Alison J. Quayle (Author)
Format: Book
Published: Hindawi Limited, 2011-01-01T00:00:00Z.
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100 1 0 |a Joyce A. Ibana  |e author 
700 1 0 |a Danny J. Schust  |e author 
700 1 0 |a Jun Sugimoto  |e author 
700 1 0 |a Takeshi Nagamatsu  |e author 
700 1 0 |a Sheila J. Greene  |e author 
700 1 0 |a Alison J. Quayle  |e author 
245 0 0 |a Chlamydia trachomatis Immune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms 
260 |b Hindawi Limited,   |c 2011-01-01T00:00:00Z. 
500 |a 1064-7449 
500 |a 1098-0997 
500 |a 10.1155/2011/420905 
520 |a Genital C. trachomatis infections typically last for many months in women. This has been attributed to several strategies by which C. trachomatis evades immune detection, including well-described methods by which C. trachomatis decreases the cell surface expression of the antigen presenting molecules major histocompatibility complex (MHC) class I, MHC class II, and CD1d in infected genital epithelial cells. We have harnessed new methods that allow for separate evaluation of infected and uninfected cells within a mixed population of chlamydia-infected endocervical epithelial cells to demonstrate that MHC class I downregulation in the presence of C. trachomatis is mediated by direct and indirect (soluble) factors. Such indirect mechanisms may aid in priming surrounding cells for more rapid immune evasion upon pathogen entry and help promote unfettered spread of C. trachomatis genital infections. 
546 |a EN 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
690 |a Infectious and parasitic diseases 
690 |a RC109-216 
655 7 |a article  |2 local 
786 0 |n Infectious Diseases in Obstetrics and Gynecology, Vol 2011 (2011) 
787 0 |n http://dx.doi.org/10.1155/2011/420905 
787 0 |n https://doaj.org/toc/1064-7449 
787 0 |n https://doaj.org/toc/1098-0997 
856 4 1 |u https://doaj.org/article/6f08c257468c4d4a92986d1ac80c0cc1  |z Connect to this object online.