Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study.

• Main Authors: Jose Xavier-Neto (Author), Murilo Carvalho (Author), Bruno Dos Santos Pascoalino (Author), Alisson Campos Cardoso (Author), Ângela Maria Sousa Costa (Author), Ana Helena Macedo Pereira (Author), Luana Nunes Santos (Author), Ângela Saito (Author), Rafael Elias Marques (Author), Juliana Helena Costa Smetana (Author), Silvio Roberto Consonni (Author), Carla Bandeira (Author), Vivian Vasconcelos Costa (Author), Marcio Chaim Bajgelman (Author), Paulo Sérgio Lopes de Oliveira (Author), Marli Tenorio Cordeiro (Author), Laura Helena Vega Gonzales Gil (Author), Bianca Alves Pauletti (Author), Daniela Campos Granato (Author), Adriana Franco Paes Leme (Author), Lucio Freitas-Junior (Author), Carolina Borsoi Moraes Holanda de Freitas (Author), Mauro Martins Teixeira (Author), Estela Bevilacqua (Author), Kleber Franchini (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental disruption induced by ZIKV hematogenic infection. The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing...