Microbicidal Activity of Hypothiocyanite against Pneumococcus
Infections caused by <i>Streptococcus pneumoniae</i> (pneumococcus, <i>Spn</i>) manifest in several forms such as pneumonia, meningitis, sinusitis or otitis media and are associated with severe morbidity and mortality worldwide. While current vaccines and antibiotics are avai...
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| Main Authors: | , |
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| Format: | Book |
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MDPI AG,
2021-10-01T00:00:00Z.
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| Summary: | Infections caused by <i>Streptococcus pneumoniae</i> (pneumococcus, <i>Spn</i>) manifest in several forms such as pneumonia, meningitis, sinusitis or otitis media and are associated with severe morbidity and mortality worldwide. While current vaccines and antibiotics are available to treat <i>Spn</i> infections, the rise of antibiotic resistance and limitations of the vaccines to only certain <i>Spn</i> serotypes urge the development of novel treatments against <i>Spn</i>. Hypothiocyanite (OSCN-) is a natural antimicrobial product produced by the body's own innate immune system to fight a variety of pathogens. We recently showed that OSCN- is also capable of killing <i>Spn</i> in vitro. OSCN- is an oxidative agent attacking microbes in a nonspecific manner, is safe for the host and also has anti-inflammatory effects that make it an ideal candidate to treat a variety of infections in humans. However, OSCN- has a short life span that makes its use, dosage and administration more problematic. This minireview discusses the antimicrobial mechanism of action of OSCN- against <i>Spn</i> and elaborates on the potential therapeutic use of OSCN- against <i>Spn</i> and other infectious agents, either alone or in combination with other therapeutic approaches. |
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| Item Description: | 10.3390/antibiotics10111313 2079-6382 |