Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET)

• Main Authors: Yu Lan (Author), Ping Bai (Author), Zude Chen (Author), Ramesh Neelamegam (Author), Michael S. Placzek (Author), Hao Wang (Author), Stephanie A. Fiedler (Author), Jing Yang (Author), Gengyang Yuan (Author), Xiying Qu (Author), Hayden R. Schmidt (Author), Jinchun Song (Author), Marc D. Normandin (Author), Chongzhao Ran (Author), Changning Wang (Author)
• Format: Book
• Published: Elsevier, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays a major role in various pathological conditions in the central nervous system (CNS), implicated in several neuropsychiatric disorders. Imaging of σ1R in the brain using positron emission tomography (PET) could serve as a noninva...