Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimate...
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| Main Authors: | , , , |
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| Format: | Book |
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Hindawi Limited,
2010-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus. |
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| Item Description: | 0962-9351 1466-1861 10.1155/2010/792393 |