Cationic Polymer-Coated Magnetic Nanoparticles with Antibacterial Properties: Synthesis and In Vitro Characterization
Uniformly sized magnetite nanoparticles (<i>D</i><sub>n</sub> = 16 nm) were prepared by a thermal decomposition of Fe(III) oleate in octadec-1-ene and stabilized by oleic acid. The particles were coated with Sipomer PAM-200 containing both phosphate and methacrylic groups ava...
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MDPI AG,
2021-09-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_6fe7dbad7c7a4e868f41e11b969c29dc | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Anastasiia B. Shatan |e author |
| 700 | 1 | 0 | |a Vitalii Patsula |e author |
| 700 | 1 | 0 | |a Aneta Dydowiczová |e author |
| 700 | 1 | 0 | |a Kristýna Gunár |e author |
| 700 | 1 | 0 | |a Nadiia Velychkivska |e author |
| 700 | 1 | 0 | |a Jiřina Hromádková |e author |
| 700 | 1 | 0 | |a Eduard Petrovský |e author |
| 700 | 1 | 0 | |a Daniel Horák |e author |
| 245 | 0 | 0 | |a Cationic Polymer-Coated Magnetic Nanoparticles with Antibacterial Properties: Synthesis and In Vitro Characterization |
| 260 | |b MDPI AG, |c 2021-09-01T00:00:00Z. | ||
| 500 | |a 10.3390/antibiotics10091077 | ||
| 500 | |a 2079-6382 | ||
| 520 | |a Uniformly sized magnetite nanoparticles (<i>D</i><sub>n</sub> = 16 nm) were prepared by a thermal decomposition of Fe(III) oleate in octadec-1-ene and stabilized by oleic acid. The particles were coated with Sipomer PAM-200 containing both phosphate and methacrylic groups available for the attachment to the iron oxide and at the same time enabling (co)polymerization of 2-(dimethylamino)ethyl methacrylate and/or 2-<i>tert</i>-butylaminoethyl methacrylate at two molar ratios. The poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and poly[2-(dimethylamino)ethyl methacrylate-<i>co</i>-2-<i>tert</i>-butylaminoethyl methacrylate] [P(DMAEMA-TBAEMA)] polymers and the particles were characterized by <sup>1</sup>H NMR spectroscopy, size-exclusion chromatography, transmission electron microscopy, dynamic light scattering, thermogravimetric analysis, magnetometry, and ATR FTIR and atomic absorption spectroscopy. The antimicrobial effect of cationic polymer-coated magnetite nanoparticles tested on both <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> bacteria was found to be time- and dose-responsive. The P(DMAEMA-TBAEMA)-coated magnetite particles possessed superior biocidal properties compared to those of P(DMAEMA)-coated one. | ||
| 546 | |a EN | ||
| 690 | |a magnetic | ||
| 690 | |a nanoparticles | ||
| 690 | |a antibacterial activity | ||
| 690 | |a 2-(dimethylamino)ethyl methacrylate | ||
| 690 | |a 2-<i>tert</i>-butylaminoethyl methacrylate | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antibiotics, Vol 10, Iss 9, p 1077 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/2079-6382/10/9/1077 | |
| 787 | 0 | |n https://doaj.org/toc/2079-6382 | |
| 856 | 4 | 1 | |u https://doaj.org/article/6fe7dbad7c7a4e868f41e11b969c29dc |z Connect to this object online. |