Intrathecally Administered Apelin-13 Alleviated Complete Freund's Adjuvant-Induced Inflammatory Pain in Mice

• Main Authors: Shuangyu Lv (Author), Xiaomei Zhang (Author), Yuchen Zhou (Author), Yu Feng (Author), Yanjie Yang (Author), Xinchun Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apelin is the endogenous ligand for APJ, a G-protein-coupled receptor. Apelin gene and protein are widely distributed in the central nervous system and peripheral tissues. The role of apelin in chronic inflammatory pain is still unclear. In the present study, a mouse model of complete Freund's...