Confirmation of validity of the developed translational model of chronic heart failure in rats

• Main Authors: I. B. Tsorin (Author), V. V. Barchukov (Author), E. O. Ionova (Author), V. N. Stolayruk (Author), M. B. Vititnova (Author), S. A. Kryzhanovskii (Author)
• Format: Book
• Published: LLC "Publisher OKI", 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2587-7836; 2686-8830; 10.37489/2587-7836-2020-2-11-16
• Keywords: translational model; chronic postinfarction heart failure; anterior transmural myocardial infarction; echocardiography; exercise tolerance; validity; Pharmacy and materia medica; RS1-441
• Source: Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 11-16 (2020)

The exprimants based on our translational model of chronic post-infarction heart failure within the use of echocardiography showed that in animals after 90 days after the reproduction of the myocardial infarction compared to the sham operated animals there is a significant increase in the endsystolic and end-diastolic sizes of the left ventricle (respectively, from 2.49 ± 0.09 to 3.91 ± 0.17 mm, p = 0.0002, and from 3.56 ± 0.12 to 5.20 ± 0.19 mm, p = 0.0002) and the decrease of its inotropic function that indicates a simulated pathology. 5 days after the echocardiographic study, the animals' exercise tolerance was assessed in the treadmill-run to failure test. It is proved in rats that 90 days after the coronary artery litigation the tolerance of physical activity decreases sharply - the value of the distance covered by them is 109.21 ± 11.61 m, which is 2.5 times less than the distance covered by sham operated animals (p = 0.003) and 5.3 times less than the distance covered by intact rats (p = 0.0001), - which is pathognomonic for chronic heart failure and complements the data of previously conducted morpho-histological, biochemical and molecular studies, indicating that the present model reproduces the main clinical and diagnostic signs of the simulated pathology.