Non-spherical Polymeric Nanocarriers for Therapeutics: The Effect of Shape on Biological Systems and Drug Delivery Properties
This review aims to highlight the importance of particle shape in the design of polymeric nanocarriers for drug delivery systems, along with their size, surface chemistry, density, and rigidity. Current manufacturing methods used to obtain non-spherical polymeric nanocarriers such as filomicelles or...
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| Format: | Book |
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MDPI AG,
2022-12-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_707797a46f4349fe9348b93010d57959 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Prescillia Lagarrigue |e author |
| 700 | 1 | 0 | |a Filippo Moncalvo |e author |
| 700 | 1 | 0 | |a Francesco Cellesi |e author |
| 245 | 0 | 0 | |a Non-spherical Polymeric Nanocarriers for Therapeutics: The Effect of Shape on Biological Systems and Drug Delivery Properties |
| 260 | |b MDPI AG, |c 2022-12-01T00:00:00Z. | ||
| 500 | |a 10.3390/pharmaceutics15010032 | ||
| 500 | |a 1999-4923 | ||
| 520 | |a This review aims to highlight the importance of particle shape in the design of polymeric nanocarriers for drug delivery systems, along with their size, surface chemistry, density, and rigidity. Current manufacturing methods used to obtain non-spherical polymeric nanocarriers such as filomicelles or nanoworms, nanorods and nanodisks, are firstly described. Then, their interactions with biological barriers are presented, including how shape affects nanoparticle clearance, their biodistribution and targeting. Finally, their drug delivery properties and their therapeutic efficacy, both in vitro and in vivo, are discussed and compared with the characteristics of their spherical counterparts. | ||
| 546 | |a EN | ||
| 690 | |a polymeric nanocarriers | ||
| 690 | |a non-spherical | ||
| 690 | |a drug delivery | ||
| 690 | |a filomicelles | ||
| 690 | |a nanoworms | ||
| 690 | |a nanorods | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 15, Iss 1, p 32 (2022) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/15/1/32 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/707797a46f4349fe9348b93010d57959 |z Connect to this object online. |