Improved HDAC Inhibition, Stronger Cytotoxic Effect and Higher Selectivity against Leukemias and Lymphomas of Novel, Tricyclic Vorinostat Analogues

• Main Authors: Bartosz Bieszczad (Author), Damian Garbicz (Author), Marta Świtalska (Author), Marta K. Dudek (Author), Dawid Warszycki (Author), Joanna Wietrzyk (Author), Elżbieta Grzesiuk (Author), Adam Mieczkowski (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone deacetylase (HDAC) inhibitors are a class of drugs used in the cancer treatment. Here, we developed a library of 19 analogues of Vorinostat, an HDAC inhibitor used in lymphomas treatment. In Vorinostat, we replaced the hydrophobic phenyl group with various tricyclic 'caps' possessi...