Indeterminate cell histiocytosis successfully treated with phototherapy

• Main Authors: Maria Claudia Nogueira Zerbini (Author), Mirian Nacagami Sotto (Author), Fernando Peixoto Ferraz de Campos (Author), Andre Neder Ramires Abdo (Author), Juliana Pereira (Author), José Antônio Sanches Junior (Author), Jade Cury Martins (Author)
• Format: Book
• Published: University of São Paulo, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

First described in 1985, intermediate cell histiocytosis is a rare disorder of the cutaneous dendritic cell group with a varied clinical presentation and evolution. The pathologic substrate is constituted by the proliferation of indeterminate cells (ICs) that are immunophenotypically characterized by the positivity of CD1a, CD68, and faint/focal S100, plus the negativity for CD207 (langerin). The authors present the case of a healthy elderly woman who presented generalized dome-shaped reddish cutaneous nodules over her trunk, neck, face, and extremities over a period of 18 months. A laboratory and imaging work-up ruled out internal involvement. The skin biopsy was consistent with IC histiocytosis. The patient was treated with narrowband ultraviolet B phototherapy, which resulted in an excellent short-term outcome

Item Description

10.4322/acr.2016.038
2236-1960