Miquelianin Inhibits Allergic Responses in Mice by Suppressing CD4⁺ T Cell Proliferation

• Main Authors: Dae Woon Choi (Author), Sun Young Jung (Author), Gun-Dong Kim (Author), So-Young Lee (Author), Hee Soon Shin (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Allergic diseases, including atopic dermatitis (AD), induce type 2 helper T (Th2) cell-dominant immune responses. Miquelianin (quercetin 3-<i>O</i>-glucuronide, MQL) is an active compound in <i>Rosae multiflorae</i> fructus extract with anti-allergic properties. Here, we investigate the anti-allergic effects of MQL in an ovalbumin (OVA)-induced Th2-dominant mouse model and the associated mechanisms. Oral MQL suppressed cytokine and IL-2 production and proliferation of Th2 cells and upregulated heme oxygenase-1 (HO-1) in splenocytes. Ex vivo MQL suppressed Th1- and Th2-related immune responses by inhibiting CD4⁺ T cell proliferation, and upregulated HO-1 in CD4⁺ T cells by activating C-Raf-ERK1/2-Nrf2 pathway via induction of reactive oxygen species generation. In a trimellitic anhydride-induced AD-like mouse model, both topical and oral MQL ameliorated AD symptoms by suppressing Th2 immune responses. Our results suggest that MQL is a potential therapeutic agent for CD4⁺ T cell-mediated diseases, including allergic diseases.

Item Description

10.3390/antiox10071120
2076-3921