Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

• المؤلفون الرئيسيون: Joachim Berger (مؤلف), Hakan Tarakci (مؤلف), Silke Berger (مؤلف), Mei Li (مؤلف), Thomas E. Hall (مؤلف), Anders Arner (مؤلف), Peter D. Currie (مؤلف)
• التنسيق: كتاب
• منشور في: The Company of Biologists, 2014-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Nemaline myopathy is an inherited muscle disease that is mainly diagnosed by the presence of nemaline rods in muscle biopsies. Of the nine genes associated with the disease, five encode components of striated muscle sarcomeres. In a genetic zebrafish screen, the mutant träge (trg) was isolated base...