Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

• Κύριοι συγγραφείς: Joachim Berger (Συγγραφέας), Hakan Tarakci (Συγγραφέας), Silke Berger (Συγγραφέας), Mei Li (Συγγραφέας), Thomas E. Hall (Συγγραφέας), Anders Arner (Συγγραφέας), Peter D. Currie (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: The Company of Biologists, 2014-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Nemaline myopathy is an inherited muscle disease that is mainly diagnosed by the presence of nemaline rods in muscle biopsies. Of the nine genes associated with the disease, five encode components of striated muscle sarcomeres. In a genetic zebrafish screen, the mutant träge (trg) was isolated base...