Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

• मुख्य लेखकों: Joachim Berger (लेखक), Hakan Tarakci (लेखक), Silke Berger (लेखक), Mei Li (लेखक), Thomas E. Hall (लेखक), Anders Arner (लेखक), Peter D. Currie (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2014-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Nemaline myopathy is an inherited muscle disease that is mainly diagnosed by the presence of nemaline rods in muscle biopsies. Of the nine genes associated with the disease, five encode components of striated muscle sarcomeres. In a genetic zebrafish screen, the mutant träge (trg) was isolated base...