Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

• Những tác giả chính: Joachim Berger (Tác giả), Hakan Tarakci (Tác giả), Silke Berger (Tác giả), Mei Li (Tác giả), Thomas E. Hall (Tác giả), Anders Arner (Tác giả), Peter D. Currie (Tác giả)
• Định dạng: Sách
• Được phát hành: The Company of Biologists, 2014-12-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Nemaline myopathy is an inherited muscle disease that is mainly diagnosed by the presence of nemaline rods in muscle biopsies. Of the nine genes associated with the disease, five encode components of striated muscle sarcomeres. In a genetic zebrafish screen, the mutant träge (trg) was isolated base...