Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans
Vicagrel, a structural analog of clopidogrel, is now being developed as a thienopyridine antiplatelet agent in a phase II clinical trial in China. Some studies have shown that vicagrel undergoes complete first-pass metabolism in human intestine, generating the hydrolytic metabolite 2-oxo-clopidogrel...
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Frontiers Media S.A.,
2017-11-01T00:00:00Z.
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