Delayed Type Allergic Itch-Associated Response Induced by Toluene-2,4-diisocyanate in Hairless Mice

• Main Authors: Kazuhiro Fuchibe (Author), Takeshi Nabe (Author), Masanori Fujii (Author), Nobuaki Mizutani (Author), Kiichiro Danno (Author), Akihide Koda (Author), Shigekatsu Kohno (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: To develop an allergic dermatitis model showing persistent scratching in mice, toluene-2,4-diisocyanate (TDI) was repeatedly painted onto the skin of hairless HR-1 mice, and induction of itch-associated scratching behavior was observed. When HR-1 mice were epicutaneously sensitized with 1%...