Evaluation of the relationship between Hs-CRP and lipid profile in patients with hypothyroidism

• Main Authors: Ameer Abdulraheem Handhal (Author), Mahin Gholipur (Author), Fatima Mohammad zadeh (Author), Somayeh Ghorbani (Author), Safoura Khajeniazi (Author)
• Format: Book
• Published: Golestan University Of Medical Sciences, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2538-3736
• Keywords: hypothyroidism; lipid metabolism disorders; c-reactive protein; cardiovascular disease; Internal medicine; RC31-1245
• Source: Journal of Clinical and Basic Research, Vol 8, Iss 2, Pp 1-4 (2024)

Background: Hypothyroidism is a significant contributor to complications in various metabolic and cardiovascular diseases. Thyroid hormones, including lipids, play a crucial role in macromolecule metabolism. C-reactive protein (CRP) is a key marker for cardiovascular diseases and hypothyroidism independently. This study aimed to evaluate serum high-sensitivity CRP (Hs-CRP) levels, lipid profiles, and their relationship with thyroid hormones in patients with hypothyroidism compared to a control group. Methods: This case-control study included 90 participants (45 hypothyroid patients and 45 healthy controls). Blood samples were collected, centrifuged to separate serum, and analyzed using commercial kits. ELISA measured T3, T4, TSH, and Hs-CRP, while TG, HDL, LDL, VLDL, and total cholesterol were measured by spectroscopy. Results: The findings revealed higher Hs-CRP levels in hypothyroid patients compared to controls, although not statistically significant (P-value = 0.09). Hs-CRP positively correlated with TSH, T3, and TG but negatively correlated with T4, total cholesterol, VLDL, and HDL in hypothyroid subjects. These correlations were only significant between Hs-CRP and TG and Hs-CRP and LDL (P-value < 0.05). Conclusion: The positive correlation between Hs-CRP and TSH in hypothyroidism highlights a potential link between hypothyroidism and cardiovascular diseas.