The Very First Modification of Pleuromutilin and Lefamulin by Photoinitiated Radical Addition Reactions-Synthesis and Antibacterial Studies

• Main Authors: Son Thai Le (Author), Dávid Páll (Author), Erzsébet Rőth (Author), Tuyen Tran (Author), Nóra Debreczeni (Author), Miklós Bege (Author), Ilona Bereczki (Author), Eszter Ostorházi (Author), Márton Milánkovits (Author), Pál Herczegh (Author), Anikó Borbás (Author), Magdolna Csávás (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pleuromutilin is a fungal diterpene natural product with antimicrobial properties, semisynthetic derivatives of which are used in veterinary and human medicine. The development of bacterial resistance to pleuromutilins is known to be very slow, which makes the tricyclic diterpene skeleton of pleurom...