Novel Organoselenium Redox Modulators with Potential Anticancer, Antimicrobial, and Antioxidant Activities

• Main Authors: Marwa Sak (Author), Yasair S. Al-Faiyz (Author), Hany Elsawy (Author), Saad Shaaban (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Novel organic selenides were developed in good yields (up to 91%), and their chemical entities were confirmed by IR, MS, and ¹H- and ¹³C-NMR spectroscopy. Their anticancer and antimicrobial properties were estimated against different human cancer (MCF-7 and HepG2) and healthy (WI-38) cell lines, as well as several microbial strains (<i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Candida albicans</i>). Furthermore, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) bioassays were used for the estimation of the antioxidant activities. Generally, cytotoxicity results were more pronounced against the MCF-7 cells than HepG2 cells. Compound 2-((4-((1-hydroxynaphthalen-2-yl)diazenyl)phenyl)selanyl)-<i>N</i>-phenylacetamide (<b>9</b>) was the most cytotoxic, even more than doxorubicin, with IC₅₀ of 3.27 ± 0.2 against 4.17 ± 0.2 µM and twelve-times more selective, respectively. Interestingly, compound <b>9</b> exhibited similar antimicrobial potential to reference antibacterial and antifungal drugs and comparable antioxidant activity to vitamin C. These results point to selective cytotoxicity against MCF-7 cells and interesting antimicrobial and antioxidant properties of some newly synthesized organic selenides, which in turn needs further in vitro studies.

Item Description

10.3390/antiox11071231
2076-3921