The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes

• Main Authors: Sabina Sánchez-Hernández (Author), Alejandra Gutierrez-Guerrero (Author), Rocío Martín-Guerra (Author), Marina Cortijo-Gutierrez (Author), María Tristán-Manzano (Author), Sandra Rodriguez-Perales (Author), Laura Sanchez (Author), Jose Luis Garcia-Perez (Author), Jesus Chato-Astrain (Author), Ricardo Fernandez-Valades (Author), Ana Belén Carrillo-Galvez (Author), Per Anderson (Author), Rosa Montes (Author), Pedro J. Real (Author), Francisco Martin (Author), Karim Benabdellah (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Integration-defective lentiviral vectors (IDLVs) have become an important alternative tool for gene therapy applications and basic research. Unfortunately, IDLVs show lower transgene expression as compared to their integrating counterparts. In this study, we aimed to improve the expression levels of...