Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5‐lipoxygenase and stability in human blood and HepaRG cells

• Главные авторы: Maroua Mbarik (Автор), Samuel J. Poirier (Автор), Jérémie Doiron (Автор), Ayyoub Selka (Автор), David A. Barnett (Автор), Marc Cormier (Автор), Mohamed Touaibia (Автор), Marc E. Surette (Автор)
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• Опубликовано: Wiley, 2019-10-01T00:00:00Z.
• Предметы: article
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Abstract 5‐lipoxygenase (5‐LO) catalyzes the biosynthesis of leukotrienes, potent lipid mediators involved in inflammatory diseases, and both 5‐LO and the leukotrienes are validated therapeutic targets. Caffeic acid phenethyl ester (CAPE) is an effective inhibitor of 5‐LO and leukotriene biosynthesi...