Prediction of the Impact of CYP2C19 Polymorphism on Drug-Drug Interaction between Voriconazole and Tacrolimus Using Physiologically-Based Pharmacokinetic Modelling

• Main Authors: Zhi-Ping Jin (Author), Miao Yan (Author), Si-Ze Li (Author), Bao-Qing Wang (Author), Qing Xu (Author), Wei Wu (Author), Xiao-Yu Li (Author), Qian-Zhou Lv (Author), Xiao-Qiang Xiang (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Voriconazole increases tacrolimus blood concentration significantly when coadministrated. The recommendation of reducing tacrolimus to 1/3 in voriconazole package insert seems not to be satisfactory in clinical practice. In vitro studies demonstrated that the magnitude of inhibition depends...