Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation-A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial

• Main Authors: Fieke Terstappen (Author), Anne E. Richter (Author), A. Titia Lely (Author), Freek E. Hoebeek (Author), Ayten Elvan-Taspinar (Author), Arend F. Bos (Author), Wessel Ganzevoort (Author), Anouk Pels (Author), Petra M. Lemmers (Author), Elisabeth M. W. Kooi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Sildenafil is under investigation as a potential agent to improve uteroplacental perfusion in fetal growth restriction (FGR). However, the STRIDER RCT was halted after interim analysis due to futility and higher rates of persistent pulmonary hypertension and mortality in sildenafil-expose...