The pharmacology and therapeutic potential of (-)-huperzine A
Maung Kyaw Moe Tun, Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USAAbstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegen...
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| Main Authors: | , |
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| Format: | Book |
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Dove Medical Press,
2012-09-01T00:00:00Z.
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| Summary: | Maung Kyaw Moe Tun, Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USAAbstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (–)-huperzine A (1). Synthetic studies of (–)-huperzine A (1) aimed at enabling its development as a pharmaceutical will be described.Keywords: Alzheimer's, NMDA, neurodegeneration, natural products, synthesis |
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| Item Description: | 1179-1454 |