Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block Therapy

• Main Authors: Trupti Balasaheb Bhosale (Author), Vabitha Shetty (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0970-9290; 1998-3603; 10.4103/ijdr.ijdr_88_23
• Keywords: malondialdehyde; obstructive sleep apnea; salivary biomarkers; tumor necrosis factor-alpha; twin block appliance; Dentistry; RK1-715
• Source: Indian Journal of Dental Research, Vol 34, Iss 4, Pp 391-395 (2024)

Background: Disturbances in sleep have a wide-ranging effect on a child's life profoundly impacting the standard of living. The aim of this study was to investigate levels of Salivary Tumor Necrosis Factor-Alpha (TNF-α) and Malondialdehyde (MDA) in a group of children with class II malocclusion and sleep problems before and after twin block appliance therapy. Materials and Methods: Eleven children aged 8-12 years with skeletal class II malocclusion and at least one sleep disorder participated in the study. All children were subjected to a recording of their sleep history and a clinical and radiographic examination. Pre-treatment levels of salivary TNF-α and MDA were recorded. A twin block appliance was custom made and delivered to every child. After a minimum follow-up period of 9 months, all children were recalled for a re-evaluation of salivary biomarker levels. Results: Levels of salivary biomarkers TNF-α and MDA significantly decreased in children following myofunctional therapy using a twin block appliance. Conclusion: The measurement of TNF-α and MDA could be used as an alternative and noninvasive method to evaluate prognosis of twin block therapy for children with sleep-disordered breathing (SDB).