Phenotypic and Genotypic Characterization of Pan-Drug-Resistant <i>Klebsiella pneumoniae</i> Isolated in Qatar
In secondary healthcare, carbapenem-resistant Enterobacterales (CREs), such as those observed in <i>Klebsiella pneumoniae</i>, are a global public health priority with significant clinical outcomes. In this study, we described the clinical, phenotypic, and genotypic characteristics of th...
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| Main Authors: | , , , , , |
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| Format: | Book |
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MDPI AG,
2024-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | In secondary healthcare, carbapenem-resistant Enterobacterales (CREs), such as those observed in <i>Klebsiella pneumoniae</i>, are a global public health priority with significant clinical outcomes. In this study, we described the clinical, phenotypic, and genotypic characteristics of three pan-drug-resistant (PDR) isolates that demonstrated extended resistance to conventional and novel antimicrobials. All patients had risk factors for the acquisition of multidrug-resistant organisms, while microbiological susceptibility testing showed resistance to all conventional antimicrobials. Advanced susceptibility testing demonstrated resistance to broad agents, such as ceftazidime-avibactam, ceftolozane-tazobactam, and meropenem-vaborbactam. Nevertheless, all isolates were susceptible to cefiderocol, suggested as one of the novel antimicrobials that demonstrated potent in vitro activity against resistant Gram-negative bacteria, including CREs, pointing toward its potential therapeutic role for PDR pathogens. Expanded genomic studies revealed multiple antimicrobial-resistant genes (ARGs), including <i>bla</i><sub>NMD-5</sub> and <i>bla</i><sub>OXA</sub> derivative types, as well as a mutated outer membrane porin protein (OmpK37). |
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| Item Description: | 10.3390/antibiotics13030275 2079-6382 |