Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysis
Objective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns. Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and L...
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2013-01-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_74b95ca5fd8a4a8bb16b51c2511bbf58 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Wanderley Marques Bernardo |e author |
700 | 1 | 0 | |a Felipe Toyama Aires |e author |
700 | 1 | 0 | |a Renata Mota Carneiro |e author |
700 | 1 | 0 | |a Fernando Pereira de Sá |e author |
700 | 1 | 0 | |a Vera Esteves Vagnozzi Rullo |e author |
700 | 1 | 0 | |a Dennis Alexander Burns |e author |
245 | 0 | 0 | |a Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysis |
260 | |b Elsevier, |c 2013-01-01T00:00:00Z. | ||
500 | |a 0021-7557 | ||
500 | |a 10.1016/j.jped.2013.02.004 | ||
520 | |a Objective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns. Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) AND (probiotics). Results: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT = 25), overall death (NNT = 34), and neonatal sepsis (NNT = 34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p < 0.001) and hospitalization time (p < 0.001) when compared to those not receiving probiotics. There was no difference in mortality caused by NEC. Conclusion: In premature newborns, the use of probiotics is effective as a prophylaxis for NEC and its complications. Resumo: Objetivo: Elucidar os benefícios do uso de probióticos na prevenção de enterocolite necrosante (ECN) e de suas complicações em recém-nascidos prematuros. Método: Revisão sistemática de ensaios clínicos randomizados, que incluiu pesquisas efetuadas em três bases de dados (MEDLINE, EMBASE e LILACS), utilizando a combinação dos termos (necrotizing enterocolitis) AND (probiotics). Resultados: Foram incluídos 11 ensaios clínicos randomizados, totalizando 2.887 pacien- tes, sendo 1.431 no grupo Probiótico e 1.456 no grupo Controle. Houve redução na incidência de ECN (NNT = 25), de morte global (NNT = 34) e sepse neonatal (NNT = 34) no grupo Probiótico em relação ao grupo Controle. Pacientes alimentados com suple- mentação de probióticos tiveram tempo de reintrodução alimentar (p < 0,001) e de hospitalização (p < 0,001) menor quando comparados aos que não receberam. Não houve diferença na mortalidade causada por ECN. Conclusão: Em recém-nascidos prematuros, o uso de probióticos é eficaz na profilaxia de ECN e de suas complicações. Keywords: Home oxygen therapy, Children, Oxygen, Palavras-chave: Enterocolite necrosante, Probióticos, Prematuros | ||
546 | |a EN | ||
690 | |a Pediatrics | ||
690 | |a RJ1-570 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Jornal de Pediatria, Vol 89, Iss 1, Pp 18-24 (2013) | |
787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S0021755713000053 | |
787 | 0 | |n https://doaj.org/toc/0021-7557 | |
856 | 4 | 1 | |u https://doaj.org/article/74b95ca5fd8a4a8bb16b51c2511bbf58 |z Connect to this object online. |