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Wild and Cultivated <i>Centaurea raphanina</i> subsp. <i>mixta</i>: A Valuable Source of Bioactive Compounds

<i>Centaurea raphanina</i> subsp. <i>mixta</i> (DC.) Runemark is a wild edible species endemic to Greece. This study evaluated the chemical composition and bioactive properties of wild and cultivated <i>C. raphanina</i> subsp. <i>mixta</i> plants. Wild...

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Bibliographic Details
Main Authors:	Spyridon A. Petropoulos (Author), Ângela Fernandes (Author), Maria Ines Dias (Author), Carla Pereira (Author), Ricardo Calhelha (Author), Francesco Di Gioia (Author), Nikolaos Tzortzakis (Author), Marija Ivanov (Author), Marina Sokovic (Author), Lillian Barros (Author), Isabel C. F. R. Ferreira (Author)
Format:	Book
Published:	MDPI AG, 2020-04-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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Summary:	<i>Centaurea raphanina</i> subsp. <i>mixta</i> (DC.) Runemark is a wild edible species endemic to Greece. This study evaluated the chemical composition and bioactive properties of wild and cultivated <i>C. raphanina</i> subsp. <i>mixta</i> plants. Wild plants had higher nutritional value than cultivated ones, whereas cultivated plants contained more tocopherols. Glucose and sucrose were higher in cultivated plants and trehalose in wild ones. Oxalic and total organic acids were detected in higher amounts in cultivated samples. The main fatty acids were α-linolenic, linoleic and palmitic acid, while wild plants were richer in polyunsaturated fatty acids. Two pinocembrin derivatives were the main phenolic compounds being detected in higher amounts in wild plants. Regarding the antioxidant activity, wild and cultivated plants were more effective in the oxidative haemolysis (OxHLIA) and thiobarbituric acid reactive substances (TBARS) assays, respectively. Moreover, both extracts showed moderate cytotoxicity in non-tumor cell lines (PLP2), while cultivated plants were more effective against cervical carcinoma (HeLa), breast carcinoma (MCF-7) and non-small lung cancer (NCI-H460) cell lines. Finally, wild plants showed higher antimicrobial activity than cultivated plants against specific pathogens. In conclusion, the cultivation of <i>C.</i> <i>raphanina</i> subsp. <i>mixta</i> showed promising results in terms of tocopherols content and antiproliferative effects, however further research is needed to decrease oxalic acid content.
Item Description:	10.3390/antiox9040314 2076-3921