CYP3A5 influences oral tacrolimus pharmacokinetics and timing of acute kidney injury following allogeneic hematopoietic stem cell transplantation

• Main Authors: Nathan D. Seligson (Author), Xunjie Zhang (Author), Mark C. Zemanek (Author), Jasmine A. Johnson (Author), Zachary VanGundy (Author), Danxin Wang (Author), Mitch A. Phelps (Author), Julianna Roddy (Author), Craig C. Hofmeister (Author), Junan Li (Author), Ming J. Poi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Polymorphisms in genes responsible for the metabolism and transport of tacrolimus have been demonstrated to influence clinical outcomes for patients following allogeneic hematologic stem cell transplant (allo-HSCT). However, the clinical impact of germline polymorphisms specifically fo...